23 5月 2018

Immunosuppression Series – Cyclosporin

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Cyclosporin is the generic form of the brand-name drug SQ-Cimmun, it’s one of the basic immunosuppressant. Widely used in autoimmune diseases, organ transplant rejection other areas of the treatments.

Aescu Pharma will provide 3 different type of Cyclosporin to our distributor:

Suggestion: Cyclosporin usually combined with sirolimus or mycophenolate mofetil dispersible tablets together.
If you interesting in this product, please send email to sales@aescupharma.com. You also can check below information to know more about Cyclosporin.

“Immunosuppressants widely used to prevent organ transplant rejection”

Treatment:

  • It is used to prevent the allograft rejection such as kidney, liver, heart, and bone marrow, etc organ or tissues and effective treatment of new-onset diabetes after kidney transplantation.
  • It is used to prevent graft-versus-host disease(GVHD) during bone marrow transplantation
  • It’s also a classical drug of the application of stem cell transplantation
  • It could be used to treat psoriasis that approved by FDA, and also treat systemic lupus erythematosus (SLE) without any side effect on organ.
  • Exclusive effectively treat lupus nephritis, refractory nephrotic syndrome, etc autoimmune diseases when the other immunosuppressants are useless.
  • Reported in recent years, it’s also can treat for uveitis, severe aplastic anemia(saa), and refractory autoimmune thrombocytopenic purpura, etc. Cyclosporin is the front-line option of the autoimmune related blood disease, effectively treat autoimmune hemolytic anemia(AIHA), aplastic anemia(AA), Immune Thrombocytopenia(ITP).

SQ-Cimmun usually combined with immunosuppressive agents such as adrenal corticosteroids have good curative effect. It’s also can instead of Tacrolimus(FK506).

Cyclosporine is a fat-soluble cyclic undecapeptide compound produced by tolypocladium inflatum, It selectively acts on the initial stage of T lymphocytes activation. Adjuvanticity T cell are activated to generate the proliferation factor interleukin(interleukin 2,IL-2),Cyclosporine will inhibits IL-2, but it’s not effect on suppressor T cells. The other important function is cyclosporine can inhibits lymphocyte to generation interferon. It has no effect on reticuloendothelial phagocyte. Thus cyclosporine is different with the function of cytotoxic drugs. It’s only inhibits the cellular immunity mediated by T cells, it’s not affect the general defense ability of the body.

Advantage:

  • Non inhibition of bone marrow, hardly induce infection, safety to use.
  • Steady blood concentration, reduce the individual difference.
  • The micro-emulsion by high-tech equipment makes the product have good dispersion and water-solubility, which is means the product is much easier to be absorbed by intestine.
  • Effectively reduce the incidence of acute rejection.
  • Effectively reduce new-onset diabetes after renal transplantation, and patients with positive hepatitis C are more effective
  • Good efficacy and tolerance.

Interactions

  • In combination with estrogen, androgen, cimetidine, diltiazem, erythromycin, ketoconazole, it’s will increase the plasma concentration of the product to lead increase the liver and kidney toxicity of this product. Therefore, if you take cyclosporine with above medicine together, patients should be monitored for liver and kidney function and plasma concentrations of the product.
  • In combination with indomethacin and other non-steroidal anti-inflammatory analgesics, the risk of renal failure may increase.
  • In combination with liver enzyme inducers: It’s will induce liver microsomal enzymes to increase the metabolism of the product. Therefore, the dose of the product must be adjusted.
  • In combination with adrenocorticotropic hormone, azathioprine, chlorambucil, cyclophosphamide and other immunosuppressants, it’s may increase the risk of infection and lymphoproliferative disease, should be cautious.
  • In combination with lovastatin in heart transplant patients, it is possible to increase the risk of rhabdomyolysis and acute renal failure.
  • In combination with drugs that cause nephrotoxicity, it can increase the toxicity to the kidneys, If renal insufficiency occurs, reduce the dose of the drug or stop the drug.

Side Effect:

  • More common are gastrointestinal reactions such as anorexia, nausea, vomiting, also have gingival hyperplasia with hemorrhage, pain, and about 1/3 of patients have renal toxicity. May occur serum creatinine, increased urea nitrogen, reduced glomerular filtration rate, etc renal impairment and hypertension.
  • None common is convulsions, the reason may be related to the kidney toxicity and hypomagnesemia

Faithfully yours,
Aescu Marketing Team

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