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Co-Trimoxazole Powder for Suspension

Brands: SQ-Cotrizole; Oral Preparation; Drug class: Antifungal
Specification/Dosage: 240mg/5mL
Packaging: 60ml bottle/box, 100ml bottle/box

SQ-Cotrizole(Co-Trimoxazole) Uses:

Co-Trimoxazole powder for suspension is the generic form of the brand-name drug SQ-Cotrizole, a drug treat following infections caused by sensitive strains:

  • Urinary tract infections caused by Escherichia coli, Klebsiella, Enterobacter, Proteus mirabilis, Proteus vulgaris, and Morgenella sensitive strains.
  • Acute otitis media in children older than 2 years old caused by Streptococcus pneumoniae or Haemophilus influenzae.
  • Acute exacerbation of adult chronic bronchitis caused by Streptococcus pneumoniae or Haemophilus influenzae.
  • Intestinal infections and Shigella infections caused by Freund’s or Shigella spp. sensitive strains.
  • Treatment of Pneumocystis carinii pneumonia, the strain of choice.
  • Pneumocystis carinii pneumonia prevention may be used in patients with a history of at least one episode of Pneumocystis carinii, or in HIV-infected adults, with a CD4 lymphocyte count ≤200/mm3 or less than the total number of lymphocytes 20 %.
  • Diarrhea in tourists caused by enterotoxigenic E. coli (ETEC).

Co-Trimoxazole us a composite made of sulfamethoxazole and trimethoprim, sulfamethoxazole is a mid-effective sulfonamide, Trimethoprim is a sulfonamide synergist, The general formula is 5:1. The formula not only reduces the side effects, but also greatly increases the antibacterial spectrum and antibacterial activity. It has the advantages of wide antibacterial spectrum, rapid absorption and less adverse reactions. It is commonly used in the treatment of respiratory tract, urinary tract infection and typhoid fever, cell dysentery, etc.

Allergic reactions are more common and may be manifested as drug eruptions. Severe cases may develop exudative erythema multiforme, exfoliative dermatitis, and epidermolysis bullosa atrophic dermatitis; There are also serological reactions such as photosensitivity, drug fever, joint and muscle pain, and fever. Occasionally anaphylactic shock.
Neutropenia or deficiency, thrombocytopenia, and aplastic anemia. Patients may present with sore throat, fever, paleness and bleeding tendency.
Hemolytic anemia and hemoglobinuria. This is apt to occur after the application of sulfa drugs in patients lacking glucose-6-phosphate dehydrogenase, and is more common in newborns and children than in adults.
Hyperbilirubinemia and neonatal kernicterus. Because the product competes with bilirubin for protein binding sites, it can cause increased free bilirubin. Neonatal liver function is not perfect, poor treatment of bilirubin, it is more prone to hyperbilirubinemia and neonatal jaundice, even nuclear jaundice can occur.
Liver damage. Jaundice can occur, liver dysfunction, severe acute liver necrosis can occur.
Kidney damage. Crystalluria, hematuria, and tubular urine can occur; occasionally patients have serious adverse reactions to interstitial nephritis or tubular necrosis.
Nausea, vomiting, loss of appetite, diarrhea, headache, fatigue, etc. The general symptoms are mild. Occasionally, C. difficile enteritis occurs in patients, and it is necessary to stop the drug at this time.

Prone to crystalline urine, hematuria, proteinuria, oliguria, low back pain. Patients with hepatic insufficiency should not use compound sulfamethoxazole.
Cross allergic reaction. Patients who are allergic to a sulfa drug may also be allergic to other sulfa drugs.
Liver damage. Jaundice can occur, liver dysfunction, severe acute liver necrosis can occur, so patients with liver damage should avoid the application.
Kidney damage. Crystalline urine, hematuria, and tubular urine may occur. Therefore, drinking more water should be used during the administration of the product to maintain high urine flow rate. If the product is used for a long course of treatment and the dose is large, besides drinking water, it is appropriate to take sodium bicarbonate in order to prevent it. This adverse reaction.
Patients who are allergic to furosemide, sulfones, thiazide diuretics, sulfonylureas, and carbonic anhydrase inhibitors may also be allergic to sulfa drugs.

Active Ingredients: Sulfamethoxazole 200mg and trimethoprim 40mg.
Standard: USP, BP, CP
Dossier: ACTD, CTD or According client requirement
Shelf life: 3 years(36 months)
Manufacturers(factory) made in China

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