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Indometacin Capsule

Brands: S.Q-Indomcin; Oral Preparation; Drug Class: NSAIDs
Specification/Dosage: 25mg
Packaging: 10 capsules x 1 blister/box, 10 capsules x 2 blister/box, 10 capsules x 10 blister/box; Others

S.Q-Indomcin(Indometacin) Uses:

Indometacin capsules is the generic form of the brand-name drug S.Q-Indomcin, a drug indications for: Arthritis can relieve pain and swelling; Soft tissue injury and inflammation; Antipyretic; Others: It is used to treat migraine, dysmenorrhea, post-operative pain, post-traumatic pain and so on.

Side effect:

  • Gastrointestinal tract: Indigestion, stomach pain, stomach burning sensation, nausea and acid reflux, ulcers, stomach bleeding, and gastric perforation;
  • Nervous system: headache, dizziness, anxiety, insomnia, etc. Severe persons may have mental and behavioral disorders or convulsions;
  • Kidney: hematuria, edema, and renal insufficiency are common in the elderly;
  • All types of rash, the most serious one is bullous erythema multiforme;
  • The hematopoietic system is inhibited with aplastic anemia, leukopenia or thrombocytopenia;
  • Allergic reactions, asthma, angioedema, and shock.

Warning:

  • Patients with active ulcer disease, ulcerative colitis and medical history, epilepsy, Parkinson’s disease and mental illness, liver and kidney dysfunction, angioneurotic edema or hypersensitivity to this product or to aspirin or other non-steroidal anti-inflammatory drugs Bronchial asthma disabled.
  • Cross-allergy: This product is cross-allergic to aspirin. Patients with wheezing caused by aspirin allergy can cause bronchospasm when using this product. Allergic to other non-steroidal anti-inflammatory and analgesic drugs may also be allergic to this product.
  • This product has a strong antipyretic effect, usually once taken 6.25mg or 12.5mg can quickly and significantly reduce fever, it should prevent profuse sweat and prostration, add enough fluid.
  • This product has an inhibitory effect on platelet aggregation, can extend the bleeding time, after the withdrawal of this effect can be sustained for 1 day, blood urea nitrogen and serum creatinine levels are often increased during treatment.

Interactions:

  • The long-term use of acetaminophen increases renal toxicity, and the incidence of peptic ulcer increases with other non-steroidal anti-inflammatory drugs.
  • When used in combination with aspirin or other salicylates, it does not enhance efficacy, but gastrointestinal adverse reactions are significantly increased, and the effect of inhibiting platelet aggregation is enhanced to increase bleeding tendency.
  • Drinking alcohol or with corticosteroids and adrenocorticotropic hormone can increase the risk of gastrointestinal ulcers or bleeding.
  • When used with digitalis drugs, this product can increase the blood concentration of digitalis (due to inhibition of clearance from the kidneys) and increase toxicity, and therefore need to adjust the dose of digitalis.
  • When combined with heparin, oral anticoagulant and thrombolytic drugs, this product will compete with the binding protein to increase the anticoagulant effect. At the same time, this product inhibits platelet aggregation and therefore has the potential to increase bleeding.
  • This product is combined with insulin or oral hypoglycemic agents to enhance the hypoglycemic effect and to adjust the dose of hypoglycemic drugs.
  • Combined with triamterene, it can cause decreased renal function (decrease in creatinine clearance, azotemia).
  • When the product is used together with nifedipine or verapamil, the blood concentration of the latter two can be increased, and thus the toxicity increases.
  • Probenecid can reduce the clearance of the product from the kidneys and bile, increase the plasma concentration, increase the toxicity, and reduce the amount when combined.
  • In combination with colchicine and sulfinpyra, the risk of gastrointestinal ulcers and bleeding can be increased.
  • When used with a lithium salt, it can reduce the excretion of lithium from the urine, increase the blood drug concentration, and increase the toxicity.
  • When used together with the antiviral drug zidovudine, the clearance rate of the latter can be reduced and the toxicity can be increased. At the same time, the toxicity of this product has also increased, so it should be avoided.

Other Information

  • Active Ingredients: Indometacin 25mg
  • Standard: USP; BP; CP
  • Dossier: ACTD, CTD or According client requirement
  • Shelf life: 3 years(36 months)
  • Manufacturers(factory) made in China

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